Cisplatin pulmonary toxicity

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August undefined, 2024

WebCisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose limiting. WebRenal toxicity is a prominent component of the toxicity profile of platinum-based chemotherapy. Kidney damage, once dose limiting for cisplatin, occurs in some patients who receive carboplatin and may occur with the third-generation platinum analog ormaplatin.

Cisplatin Mouse Models: Treatment, Toxicity and Translatability …

WebIn group 1, cisplatin was administered at a dose of 60 mg/m2 to four cats. In an attempt to avoid renal toxicity, saline diuresis was induced by administering 0.9% saline solution … WebSep 15, 2024 · Common side effects include nausea, vomiting, bone marrow suppression, electrolyte imbalance, neuropathy, ototoxicity and nephrotoxicity. Cisplatin is mutagenic, … dansby white

Adverse Cardiac Manifestations of Cisplatin - A Review

WebIntroduction: The aim of this multicenter phase II trial was to evaluate the combination of oral vinorelbine and cisplatin with radiotherapy (RT) after cisplatin-docetaxel induction chemotherapy (CT) in patients with locally advanced non-small cell lung cancer (NSCLC). Patients and methods: Patients with previously untreated, inoperable, histologically or … WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Targeted therapy for cisplatin-resistant lung cancer via aptamer-guided nano-zinc carriers containing USP14 siRNA. Xinmin Zhao, ... Some chronic toxicity was observed in the 10 mg ... WebSep 1, 2024 · Cisplatin for injectioncan cause dose-related nephrotoxicity, including acute renal failure that becomes more prolonged and severe with repeated courses of the drug. … dansby swanson tours the braves new clubhouse

Modulation of Oxidative Stress by Ozone Therapy in the …

Cisplatin nephrotoxicity - UpToDate

WebMay 9, 2024 · A general discussion of the clinical presentation, pathogenesis, diagnosis, differential diagnosis, and management of antineoplastic agent-induced pulmonary toxicity is covered elsewhere, as is lung toxicity associated with molecularly targeted … WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, mesothelioma, ovarian cancer, and bladder cancer. It is also used prior to bone marrow and stem cell transplantation. birthday party places edmond okWebSep 1, 2024 · Cisplatin for injection can cause severe hypersensitivity reactions, including anaphylaxis and death. Manifestations have included facial edema, wheezing, tachycardia, and hypotension. Hypersensitivity reactions have occurred within minutes of administration to patients with prior exposure toCisplatin for injection. dansby swanson wedding pictures

"WebTUBULAR TOXICITY Platinum compounds Cisplatin(cis-dichlorodiammineplatinum)–platinum coordination complex is an effective chemotherapy against a wide spectrum of tumors such as testicular, head and neck, ovarian, lung, cervical, and bladder cancers. Nephrotoxicity is the dose-limiting toxicity of cisplatin. … " - Cisplatin pulmonary toxicity

Cisplatin pulmonary toxicity

Pathophysiology of cisplatin-induced acute kidney injury

WebAug 1, 1998 · Cisplatin doses were fixed and were not reduced for any toxicity. The most common reasons for irinotecan dose reduction were nausea and vomiting (27% of patients), followed by diarrhea (21%), and neutropenia (12%). Response and Survival All patients were evaluated for response and survival. WebClinical Comparative Investigation of Efficacy and Toxicity of Cisplatin plus Clinical comparative investigation of efficacy and toxicity of cisplatin plus gemcitabine or plus Abraxane as first-line chemotherapy for stage III/IV non-small-cell lung cancer Dan Ai,1,2 Yan Guan,2 Xiu-Ju Liu,2 Chu-Feng Zhang,1,2 Peng Wang,1,2 Hong-Lu Liang,1,2 Qi …

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Webprimary pulmonary toxicity of cisplatin in cats. (Journal of Veterinary Internal Medicine. 1987; 129-35) CISPLATIN (cis-diamminedichloroplatinum) is a widely used … WebDec 7, 2024 · Extensive-stage small cell lung cancer (ES-SCLC) is an aggressive disease with poor survival, and platinum-etoposide chemotherapy is indicated as the mainstay of …

WebSep 4, 2013 · The short hydration is safe without severe renal toxicities in regimens containing cisplatin (≥75 mg/m 2) for patients with lung cancer. short hydration, magnesium supplementation, cisplatin, lung cancer, renal toxicity Topic: chemotherapy regimen cisplatin creatinine kidney failure mannitol safety kidney lung cancer pemetrexed toxic … WebPulmonary toxicity is one of the most serious adverse effects associated with a quick course of vincristine, bleomycin, and cisplatin neoadjuvant chemotherapy (NAC-VBP). The aim of this study was to evaluate pulmonary toxicity related to a quick course NAC-VBP.

WebJan 16, 2024 · Advise the patient to call 911 immediately if they develop any signs of infection (immunosuppression), experience coughing, wheezing, or shortness of breath (pulmonary toxicity), or notice unusual bleeding (liver or bone marrow suppression). WebThe TPF triplet regimen (docetaxel, cisplatin, and 5‐FU) has a trend of further improving treatment efficacy compared with the traditional doublet regimen. 35 , 36 In a phase II study, concurrent chemoradiotherapy with TPF achieved a clinical CR rate of 52.4%, much higher than the previously reported CR rate of 20%. 9 However, the high ...

WebFeb 11, 2024 · Cisplatin is a cytotoxic drug that triggers several toxicities. However, nephrotoxicity and ototoxicity remain major clinical limitations. The aim of our study was …

WebMyelosuppression is the most common toxicity of gemcitabine therapy. Pulmonary toxicities due to gemcitabine have, however, been reported. Dyspnea occurs in approximately 25% of patients treated with gemcitabine, whereas serious pulmonary toxicities are much less common, approximately 0.3%. birthday party places dallasWebApr 26, 2024 · To assess the prognostic impact of BPT, we retrospectively identified 52 patients who underwent bleomycin etoposide and cisplatin chemotherapy from 2008 to 2024 in our institution, and evaluated the risk factors of BPT and its effect on prognosis. Patients who had received chemotherapy at another institution were excluded. birthday party places etobicoke birthday party places el pasoWebFeb 22, 2024 · Lung cancer is the leading cause of cancer-related death in the Unites States, and approximately 85% of all lung cancers are classified as non-small cell lung cancer (NSCLC), which is extremely difficult to treat and its survival rate is low. After decades of clinical trials, the most effective treatments are still those that implement the … dansby swanson to the cubsWebCancer immunotherapy significantly contributed to an improvement in the prognosis of cancer patients. Immunotherapy, including human epidermal growth factor receptor 2 (HER2)-targeted therapies, immune checkpoint inhibitors (ICI), and chimeric antigen receptor-modified T (CAR-T), share the characteristic to exploit the capabilities of the … dansby swanson white jerseyWebPulmonary toxicity of cytotoxic agents Platinum compounds The administration of cisplatin and carboplatin, the 2 most commonly used platinum derivative agents, can … dan scarbroughWebBased on 4448 patients, the incidences of dyspnea and other serious pulmonary toxicity were 0.45% and 0.27% respectively. Based on an estimated 217 400 patients treated with commercial gemcitabine worldwide, the crude incidences of dyspnea and other serious pulmonary toxicity were 0.02% and 0.06% respectively. dansby\u0027s taylor rental