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NM_000321.3 (RB1):c.963del (p.Arg320_Tyr321insTer) AND …
Web15 gen 2000 · One other dysfunctional prothrombin, prothrombin Clamart, has been proposed to have a mutation at Arg320 that results in a prothrombin that cannot be activated. 16 Activation of prothrombin Clamart by Factor Xa results in the formation of prothrombin 2, indicating an impairment in cleavage at Arg320-Ile321. Web18 feb 2024 · This variant is also known as c.958C>T (p.Arg320*). ClinVar contains an entry for this variant (Variation ID: 185048). This variant is expected to delete amino acid … shop window cleaning northampton
Amide H/2H Exchange Reveals a Mechanism of Thrombin …
Web15 gen 2000 · One other dysfunctional prothrombin, prothrombin Clamart, has been proposed to have a mutation at Arg320 that results in a prothrombin that cannot be … WebThe prothrombinase complex processes prothrombin to thrombin through sequential cleavage at Arg320 followed by Arg271 when cofactor, factor (f) Va, protease, fXa, and substrate, prothrombin, are all bound to the same membrane surface. In the absence of the membrane or cofactor, cleavage occurs in th … Web1 nov 2012 · Prothrombin activation by prothrombinase (IIase or factor Xa [fXa]·fVa) involves cleavage at Arg271 and Arg320 to produce the α-thrombin (αIIa) product. 1,2 Depending on the order of cleavage, activation occurs via 2 possible intermediates; meizothrombin (mIIa) or prethrombin-2. mIIa arises from initial cleavage at Arg320, yielding a membrane … shop window cling